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While neuroinflammation is an innate mechanism designed to protect against infections and injuries, chronic or dysregulated neuroinflammation contributes to the development and progression of CNS disorders ranging from early developmental disorders such as autism spectrum disorders (ASD) (Han et al., 2021) and schizophrenia (Mller et al., 2015) to neurogenerative disorders (Zhang et al., 2023) including Alzheimers and Parkinsons disease (Gella and Durany, 2009

n = 5, analyzed by one-way ANOVA with post-hoc Tukeys t-tests

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Excess glucocorticoid exposure suppresses GH secretion mainly through the increase in hypothalamic somatostatin tone, whereas low cortisol levels causes relative GHD that is reversible by glucocorticoid therapy (Giustinas effect) ( Figure 5 ) (104)

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